Sep 15, 2025, 02:50 PM ET
Week 3 gets underway with a matchup of AFC East rivals when the Miami Dolphins visit the Buffalo Bills on "Thursday Night Football."
The Bills cruised past the New York Jets in Week 2 to move to 2-0, while the Dolphins dropped to 0-2 after falling to the Patriots in New England.
Not surprisingly, the Bills are the biggest favorite (-13.5) on the Week 3 slate.
Sunday afternoon features two matchups of undefeated teams, with the Philadelphia Eagles (-3.5) hosting the Los Angeles Rams and the Arizona Cardinals hitting the road to face the San Francisco 49ers (-1.5).
"Sunday Night Football" will feature a pair of winless teams: the New York Giants and... the Kansas City Chiefs. The Giants fell to 0-2 after a wild finish in Dallas, and the Chiefs remained winless after a loss to the Eagles in their Super Bowl rematch.
The week wraps up with an enticing "Monday Night Football" matchup, as the Detroit Lions visit the Baltimore Ravens at 8:15 p.m. ET on ABC/ESPN.
Here's a look at the odds for every Week 3 game.
Odds as of publication time. For the most current odds, visit ESPN BET.
Jump to:
MIA-BUF | NYJ-TB | IND-TEN | LV-WSH
LAR-PHI | ATL-CAR | HOU-JAX | GB-CLE
PIT-NE | CIN-MIN | DEN-LAC | NO-SEA
ARI-SF | DAL-CHI | KC-NYG | DET-BAL
Miami Dolphins vs. Buffalo Bills -13.5
Thursday, 8:15 p.m., Prime Video
Line movement: Opened Bills -10.5
Money Line: Dolphins (+550); Bills (-900)
Total: 49.5; Opened: 48.5
FPI favorite: Bills by 11.1 with a 75.87% probability to win the game outright
New York Jets vs. Tampa Bay Buccaneers -6.5
Sunday, 1 p.m., FOX
Money Line: Jets (+260); Buccaneers (-320)
Total: 44.5; Opened: 44.5
FPI favorite: Buccaneers by 7.4 with a 67.51% probability to win the game outright
Indianapolis Colts -3.5 vs. Tennessee Titans
Sunday, 1 p.m., CBS
Money Line: Colts (-185); Titans (+155)
Total: 43.5; Opened: 43.5
FPI favorite: Colts by 6.2 with a 67.53% probability to win the game outright
Las Vegas Raiders vs. Washington Commanders -5.5
Sunday, 1 p.m., FOX
Money Line: Raiders (+220); Commanders (-270)
Total: 46.5; Opened: 47.5
FPI favorite: Commanders by 4.7 with a 62.71% probability to win the game outright
Los Angeles Rams vs. Philadelphia Eagles -3.5
Sunday, 1 p.m., FOX
Money Line: Rams (+160); Eagles (-190)
Total: 44.5; Opened: 45.5
FPI favorite: Eagles by 3.1 with a 57.6% probability to win the game outright
Atlanta Falcons -3.5 vs. Carolina Panthers
Sunday, 1 p.m., FOX
Money Line: Falcons (-215); Panthers (+180)
Total: 43.5; Opened: 44.5
FPI favorite: Falcons by 2.5 with a 57.07% probability to win the game outright
Houston Texans vs. Jacksonville Jaguars -1.5
Sunday, 1 p.m., CBS
Money Line: Texans (+100); Jaguars (-120)
Total: 44.5; Opened: 43.5
FPI favorite: Jaguars by 1 with a 52.14% probability to win the game outright
Green Bay Packers -8.5 vs. Cleveland Browns
Sunday, 1 p.m., FOX
Money Line: Packers (-450); Browns (+340)
Total: 42.5; Opened: 43.5
FPI favorite: Packers by 8.4 with a 70.47% probability to win the game outright
Pittsburgh Steelers -1.5 vs. New England Patriots
Sunday, 1 p.m., CBS
Money Line: Steelers (-120); Patriots (+100)
Total: 44.5; Opened: 44.5
FPI favorite: Patriots by 0.1 with a 50.33% probability to win the game outright
Cincinnati Bengals vs. Minnesota Vikings -3.5
Sunday, 1 p.m., CBS
Line movement: Opened Vikings -5.5
Money Line: Bengals (+150); Vikings (-175)
Total: 41.5; Opened: 44.5
FPI favorite: Vikings by 0.4 with a 51.33% probability to win the game outright
Denver Broncos vs. Los Angeles Chargers -2.5
Sunday, 4:05 p.m., CBS
Money Line: Broncos (+125); Chargers (-145)
Total: 45.5; Opened: 46.5
FPI favorite: Chargers by 2.8 with a 56.51% probability to win the game outright
New Orleans Saints vs. Seattle Seahawks -7.5
Sunday, 4:05 p.m., CBS
Money Line: Saints (+300); Seahawks (-400)
Total: 41.5; Opened: 42.5
FPI favorite: Seahawks by 5.8 with a 64.2% probability to win the game outright
Arizona Cardinals vs. San Francisco 49ers -1.5
Sunday, 4:25 p.m., FOX
Line movement: Opened Cardinals -1.5
Money Line: Cardinals (+100); 49ers (-120)
Total: 44.5; Opened: 43.5
FPI favorite: Cardinals by 0.7 with a 52.33% probability to win the game outright
Dallas Cowboys vs. Chicago Bears -1.5
Sunday, 4:25 p.m., FOX
Money Line: Cowboys (+105); Bears (-125)
Total: 49.5; Opened: 49.5
FPI favorite: Cowboys by 1.5 with a 53.13% probability to win the game outright
Kansas City Chiefs -6.5 vs. New York Giants
Sunday, 8:20 p.m., NBC
Money Line: Chiefs (-275); Giants (+225)
Total: 44.5; Opened: 42.5
FPI favorite: Chiefs by 6.5 with a 66.67% probability to win the game outright
Detroit Lions vs. Baltimore Ravens -5.5
Monday, 8:15 p.m., ABC, ESPN
Money Line: Lions (+210); Ravens (-250)
Total: 51.5; Opened: 52.5
FPI favorite: Ravens by 2.4 with a 56.13% probability to win the game outright
